Reactis is used by companies around the world in the automotive, aerospace/defense, heavy equipment, medical, and energy industries as well as in academia.
Some of the organizations that have purchased Reactis are:
| Advics | Airbus | Aisin |
| Aptiv Components India Pvt. Ltd. | AVL | Azapa |
| Autoliv | BAE Systems | Bendix |
| BorgWarner | Bosch | Calsonic Kansei |
| Carmeq | Chimei Motor | China Institute of Aeronautical Radio Electronics |
| China Motor TW | Chrysler | Chung Shan Institute of Science and Technology |
| CK Electric Machinery Development | Collins Aerospace | Continental Automotive |
| DaeSung Electric | Daihatsu Motor | Daimler |
| Daimler Truck Innovation Center India | DIAS Automotive Electronic Systems China | Delphi Corporation |
| Delphi Diesel Systems | Delphi Propulsion Systems | Delphi Technical Center India |
| Delta Taiwan | Denso | DENSO TECHNO Co.,Ltd |
| Dongfeng Commercial Vehicle China | Dongfeng Motor Co., Ltd | Dongfeng Nissan Passenger Vehicle |
| Eaton | Fiat Chrysler Automobiles | Ford |
| Fraunhofer Center for Experimental Software Engineering | Fuji Heavy Industries | Fujitsu BSC Japan |
| Fujitsu Computer Technologies | GE Global Research | GE Transportation |
| General Motors | Gwangju Institute of Green-car Advancement | Hanhwa |
| Hitachi | Hitachi Astemo | Hitachi Automotive Systems, Ltd. |
| Hitachi Solutions Technology | Hitachi ULSI Systems Japan | Honda |
| Honda Elesys | Honeywell | Hyundai Autron |
| Hyundai Wia Korea | Imasen Electric Industrial | Isuzu |
| Jatco | John Deere | Karma |
| Keihin Corporation | Keihin Electronics Technology | Keihin R&D China |
| KPIT | Mando | Magneti Marelli India Pvt. Ltd. |
| Marelli | Mazda | McMaster University |
| Mercedes-Benz Research and Development | Mitsubishi | Mitsubishi Electric Control Software |
| Mitsubishi Electric Micro-Computer Application Software | Mitsubishi Motors | Mobis India |
| Nabtesco | Navistar | NASA Ames Research Center |
| Nexteer | Nissan | Nissan Techno Vietnam |
| Opel Automobile GmbH | Panasonic Advanced Technology Development | Panasonic Japan |
| Pi Innovo | Quest Global Engineering | Renault |
| Renault Nissan India | Rockwell Collins | SAIC Motor Corporation |
| SGS Taiwan | SKY Japan | Smiths Medical |
| SRM Technologies | Stellantis | Strattec |
| Suzuki Motor Corporation | Taiwan Institute of Nuclear Energy Research | Tata Consultancy Services |
| Tata Elxsi | Tata Motors | The Software Beret |
| Toyota Motor Corporation | Toyota Technical Development Corp | Toyota Tsusho Denso Electronics Thailand |
| Transtron | TRW | University of Minnesota |
| Veoneer | Vitesco | Witte Automotive France |
| Yamaha Motor Corporation | ZF |